Pyridothiadiazine derivatives as aldose reductase inhibitors having antioxidant activity

Quantitative Structure Activity Relationship Analysis of Benzimidazole Derivatives as Aldose Reductase Inhibitors

Hyperglycemia is involved in the pathogenesis of diabetic neuropathy, retinopathy, nephropathy, and macro-vascular disease via multiple mechanisms, of which increased aldose reductase activity. Aldose reductase inhibitors, when administered from the onset of hyperglycemia, prevent the progression of polyol accumulation–linked complication. In this work, we report quantitative structure activity...

Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts

The pomegranate, Punica granatum L., has been the subject of current interest as a medicinal agent with wide-ranging therapeutic indications. In the present study, pomegranate ethanolic seed and hull extracts were tested, in comparison with a commercial sample, for the inhibition of aldose reductase, an enzyme involved in the etiology of diabetic complications. In vitro inhibition of rat lens a...

Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors.

During the course of studies directed towards the discovery of novel aldose reductase inhibitors for the treatment of diabetic complications, we synthesized a series of new (Z)-3-phenyl-2-benzoylpropenoic acid derivatives and tested their in vitro inhibitory activities on rat lens aldose reductase. Of these compounds, (Z)-3-(3,4-dihydroxyphenyl)-2-(4-methylbenzoyl)propenoicacid (3k) was identif...

Aldose Reductase Inhibitors as Potential Therapeutic Drugs of Diabetic Complications

Diabetes mellitus has become a major health threat as a global rise in it has been seen. The chronic disease has afflicted over 171 million people worldwide in 2000 and the incidence is expected to grow steadily to 366 million by 2030. As of May 2008, an estimated 92 million adults in China of the most populous country were living with diabetes and 148 million adults with prediabetes [1]. Diabe...

Current status of aldose reductase inhibitors.